CATHFLO PACKAGE INSERT PDF

PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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In patients with acute ischemic stroke with uncontrolled hypertension who are otherwise eligible for alteplase therapy, increase the frequency of blood pressure monitoring if systolic blood pressure is more than mmHg or diastolic blood pressure is more than mmHg. Thank you to all who responded to my post and for ;ackage helpful information about how other practices Contraindications Cathflo Activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation.

The packagw frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding. Moderate Platelet aggregation may be impaired by selective serotonin reuptake inhibitors SSRIs due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication pacage patients receiving thrombolytic agents.

Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase.

If therapy with defibrotide is necessary, discontinue systemic fibrinolytic therapy not including use for routine maintenance or reopening of pcakage venous catheters prior to initiation of defibrotide therapy. Here is an example for declotting a dialysis cath: In clinical trials, alteplase was administered by catheter-directed intra-arterial administration. Packafe will not contact the individuals you share content with.

Monitor patients treated with Cathflo Activase for signs of hypersensitivity and treat appropriately if necessary. Mix gently by swirling until the contents completely dissolve.

Neonates, Infants, and Children weighing less than 10 kg. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed.

In the entire study population, TIMI flow grade increased from 1. Dathflo retain bioactivity for 6 months. If catheter function is not restored 2 hours after the first dose, a second dose may be instilled.

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We don’t want to “give up” too soon if practices are actually waiting this long and seeing positive results, but “chair time” may be a concern, particularly if the patient is pavkage for a long treatment that day. We often check for a blood return after 60 minutes if there insdrt no blood return at 30 minutesbut if there is still no blood return, we typically report this and request an order to treat the patient in the absence of a blood return of course, we would have assessed how the port flushes, for any other signs of problems, and would not administer a vesicant agent in the absence of a blood return.

For the mg vial: The use of alteplase for occluded central venous catheters has not been studied in patients known to be at risk for bleeding events that may be associated with use of thrombolytics. It usually was for patients who had to go to radiation since packae rural facility does not have a radiation unit nearby Our patients have pckage travel about 30 or more miles one way to get to a facility.

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Pre-treatment with oral anticoagulants is reported to be an independent risk factor for intracranial hemorrhage in thrombolytic-treated patients. Your use of third-party websites is at your own risk and subject to the terms and conditions of use cathfllo such sites. Central Venous Catheter Instillation Administration Alteplase is instilled into the occluded lumen of a central venous catheter. Leave it for the full !

Excessive pressure should be avoided when Cathflo Activase is instilled into the catheter. Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the transfer device provided by the manufacturer vertically into the insertt of the stopper.

Cathflo Activase (alteplase) dose, indications, adverse effects, interactions from

If there is still no blood return, a catheter dye study will be ordered. There was also no difference in INRs found between groups. Withdraw 2 mL into glass vials and cryopreserve at degrees C for 2 weeks; then, thaw and maintain at 22 to 24 degrees C pavkage 24 hours; then, store at degrees C for up to 19 days. Doses of 1 to 2 mg injected into the cathfko s of lnsert venous catheters or PICC lines, allowed to dwell for 15 minutes to 4 hours, then removed by aspiration, have been reported effective in establishing patency.

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Hello, We occasionally use Cathflo Activase for central lines, e. For subcutaneous ports, a dose of 2 mg diluted in 3 ml 0. If Garlic supplements are taken, monitor appropriate parameters to attain proper clinical endpoints.

Dosage & Administration – Cathflo® Activase® (alteplase)

Safety and efficacy have not been established for systemic thrombolysis; various regimens have cahtflo used. There are no data on the presence of alteplase in human milk, the effects on the breast-feeding infant, or the effects on milk production.

Insert the spike end of an infusion set through the same puncture site created by the transfer device in the stopper of the vial of reconstituted alteplase. The package insert says to assess catheter function after 30 minutes of dwell time, and if there is no blood return after packafe minutes, it says to assess “after a total of minutes of dwell time Click “OK” if you are a healthcare professional. View videos and instructions for the recommended dosing and administration of Cathflo.

Major Coadministration of edoxaban and thrombolytic agents should be avoided due to an increased risk of bleeding during concurrent use. Recombinant form of human tissue plasminogen activator Used for acute ischemic stroke, acute PE, or acute coronary arterial thromboembolism associated with evolving transmural MI Also used for the restoration of function to central venous access devices.

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Moderate Platelet aggregation may be impaired by trazodone due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication e. Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Atrial fibrillation, mitral stenosis, thrombosis.

Powered by Higher Logic. Initiate therapy as soon as possible but within 3 hours of onset of stroke symptoms. The information contained in this section of the site is intended for U. Expand all Collapse all sort by most recent sort by thread.

Hypersensitivity Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase.

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