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Amin Mirdamadian rated it it was amazing Mar 12, My primary reasons for providing a four-star review instead of five stars are 1 that the book does a good job addressing the regulatory role of the kynurenine pathway as a key component of immunoregulatory tolerance, but it does not address the crucial role of excessive and imbalanced activation of IDO in causing extreme excitotoxicity, severe oxidative stress, severe impairment of antioxidant defenses, and devastating immune system dysfunction in a wide range of treatment-refractory, chronic infections, in a wide range of neurodegenerative disorders, and in a wide range of psychiatric disorders; 2 also, I bought this book recently, but just discovered that the ninth edition was in the final stages of preparation when I paid more than I can afford for the eighth edition.
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